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In recent years, with the promotion of high-throughput sequencing in the field of reproductive health, the number of clinical samples has been increasing, and the laboratory's requirements for sample processing quality have also increased. The traditional manual construction of the library has been unable to meet the needs of the construction of the new situation. How to solve the increasingly urgent problem of library construction in the field of reproductive health? MGI gave its own answer.
High-throughput sequencing in three major applications in the field of reproductive health
What are the advantages of automated library construction compared to manual one? We used the MGISP-100 automated sample preparation system to conduct a competition:
Five advantages: sample preparation automation helps clinical promotion of reproductive detection
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Automation |
Manual operation |
|
Unattended, less fragmented time More free time for experimenter |
Frequent manual intervention Need people online all the time |
|
Processing in batches The throughput is greatly improved |
Single operation Low throughput and slow speed |
|
Standardization of the library construction process and stable production process; Convenient to copy in different labs |
It is difficult to standardize and is affected by the professional level, training level and quality of the personnel. |
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Easy to get started, Can be mastered in two days |
High professional quality and long training period |
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One machine for multi-purposes, one person can operate multi-machines Significantly reduce labor costs |
Different processes need to invest more manpower to increase throughput. |
In order to meet the needs of different application scenarios, MGI has introduced two automated sample preparation systems, MGISP-100 and MGISP-960.
(Note: MGISP-100 is the world's first automated library construction equipment that has obtained China's NMPA medical device certificate of Class II)
Customer A: customer from a Level III hospital
Situation of usage:
At the same time, three kinds of fertility tests such as NIPT, PGS and CNV were carried out, and the weekly throughput was 96 cases.
Laboratory configuration:
1 MGISP-100 with 1 basic operator.
Customer Reviews:
"MGISP-100 can realize a variety of uses on one machine. It's easy to operate, and can be used after 2 days of simple training so that we can give more time on clinical research."
Customer B: customer from a large medical laboratory
Situation of usage:
The NIPT test was carried out, and the daily throughput was about 300-600 samples.
Laboratory configuration:
3 MGISP-960 with 1 machine operator and 1 reagent preparer.
Customer Reviews:
"MGISP-960 has greatly reduced personnel input and increased daily throughput, providing us with high productivity and we no longer need to worry about the failure rate of constructing a library."
We have seen that the laboratory has achieved significant improvements in sample throughput, standardization, and economics with the use of MGI's series of automated library construction equipment. In the future, high-throughput sequencing technology will be widely used in the field of reproductive field. Automated sample preparation systems will also be further popularized.
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