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Product Description
MegaBOLT bioinformatics analysis accelerator series (including MegaBOLT/ZBOLT/ZBOLT Pro, hereinafter called MegaBOLT) is an MGI self-developed and MPS-concentrated hardware accelerating system for bioinformatics analysis.

ZBOLT Pro/ZBOLT/MegaBOLT supports the analysis of Whole Genome Sequencing (WGS), Whole Exome Sequencing (WES), and Panel Sequencing on Germline or Somatic data. It is up to 300 times faster than the classical algorithm.

Fast, integrated, easy to use, and economic are MegaBOLT's most prominent features.MegaBOLT products series include the workstation (MegaBOLT) and rack server (ZBOLT/ZBOLT Pro), which can be applied to various scenarios of all scales.
  • Laboratories
  • Hospitals
  • Research institutes
  • Enterprises


Fast

MegaBOLT adopts heterogeneous computing to accelerate analysis. It accelerates algorithms such as SOAPnuke, Minimap2, BWA, GATK HaplotypeCaller + MuTect2 through multi-stream and highly parallelized computing architecture, which contributes to a massive speedup in massive data analysis.


Analysis Time Comparison

Classical

Algorithm

MegaBOLT
ZBOLT ZBOLT Pro
Germline WGS 30X Basic 42.82h 1.50h 0.52h 0.12h
Germline WGS 30X Full 44.00h 1.94h 0.64h 0.16h
Germline WES 400X Basic 12.29h 0.34h 0.12h 0.03h
Germline WES 400X Full 12.60h 0.50h 0.16h 0.04h
Somatic WGS
40X Tumor + 40X Normal
58.20h 5.17h 1.74h 0.44h
Somatic WES
400X Tumer + 400X Normal
9.53h 0.86h 0.29h 0.07h

* Basic: Includes the analysis steps from clean data after quality control to variant calls.
* Full: Includes extra steps of quality control and report generating in addition to the Basic workflow.
* The time consumed is measured by taking the average of completing 4 identical tasks (MegaBOLT) / 12 (ZBOLT) / 48 (ZBOLT Pro).
Multi-task scheduling system acceleration
Integrated with our self-developed multi-task scheduling system, MegaBOLT supports simultaneous multi-task computing on a single server. The computing efficiency is further improved by 15%~31%.
Germline
MegaBOLT
MegaBOLT-scheduler
  • WGS 30X NA12878 DNBSEQ

  • WGS 400X NA12878 DNBSEQ

* The mean value is calculated by executing the same 4 tasks at the same time.
Precision
01.Precision
After speedup, the analysis precision remains steadfast. MegaBOLT is also configured with a deep learning variant calling module, MegaBOLT-DV, which is optimized by algorithms and specified neural network model training. When MegaBOLT is used in combination with PCR-Free library preparation and MGI DNBSEQ™ sequencing technologies, the human WGS variant calling precision can reach SNP 99.9% and INDEL 99%.

02.Deep learning making sequencing more cost-effective
The deep learning variant calling module, MegaBOLT-DV, helps to greatly reduce the sequencing depth and cost without affecting the analysis precision.
Compared with the traditional variant calling results of 30X PCR data, SNP of 15X PCR-Free data from MegaBOLT-DV is close while INDEL is better.


Tradition
MegaBOLT-DV
Integrated
Integrated with the self-developed laboratory information management system ZLIMS, MegaBOLT realizes completely automated sequencing and analysis. It can work together with MGI DNBSEQ™ sequencers or sequencers of other platforms.
  • Laboratory device management and real-time monitoring
  • Sample information recording and tracking
  • Data transmission and management
  • Analysis task scheduling and processing
  • Analysis result/report management and visualization
  • Easy to use
    The Web design makes MegaBOLT simple and easy to use. You can just click a couple of buttons to submit a task and check the results on the website. In this case, a bioinformatic technical background is no longer necessary.
     
     
  • Economic
    With a prominent speedup in computing and rigid control over hardware prime cost, a MegaBOLT server works like 10 normal computers in total and is without doubt highly cost-effective.
Heterogeneous computing accommodates
high-speed sequence analysis


MegaBOLT applies heterogeneous computing to the workflow from FASTQ input of sequencing data to BAM output of alignment result and VCF/gVCF output of variant calling result.

We also further streamlined the whole process and developed a highly parallelized computing architecture, thus realizing highspeed WGS/WES analysis and computing.




Compared with the common analysis workflow, MegaBOLT stands out for the following features:
  • Specialized hardware logic circuit for Bioinformatics computing
  • Multi-stream computing architecture
  • Highly parallelized computing architecture
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