Stopping COVID-19 is a priority worldwide. Understanding which cell types are targeted by SARS-CoV-2 virus, whether interspecies differences exist, and how variations in cell state influence viral entry is fundamental for accelerating therapeutic and preventative approaches. The endeavor profiled the transcriptome at single-cell resolution of nine tissues from a Macaca fascicularis monkey. The work constitutes a unique resource for understanding SARS-CoV-2 pathophysiology in two phylogenetically close species, which might guide in the development of effective treatments in humans.